Similar pathogen targets in Arabidopsis thaliana and homo sapiens protein networks.

Similar pathogen targets in Arabidopsis thaliana and homo sapiens protein networks.

Blog Article

We study the behavior of pathogens on host protein networks for humans and Arabidopsis - noting striking similarities.Specifically, we preform [Formula: read more see text]-shell decomposition analysis on these networks - which groups the proteins into various "shells" based on network structure.We observe that shells with a higher average degree are more highly targeted (with a power-law relationship) and that highly targeted nodes lie in read more shells closer to the inner-core of the network.Additionally, we also note that the inner core of the network is significantly under-targeted.We show that these core proteins may have a role in intra-cellular communication and hypothesize that they are less attacked to ensure survival of the host.

This may explain why certain high-degree proteins are not significantly attacked.